Anti-ErbB2/HER2 兔多克隆抗体-肿瘤标志物,原癌/抑癌基因蛋白,其它-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-ErbB2/HER2 兔多克隆抗体

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￥1900

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货号： K134869-100

预测分子量： 139 kDa

观测分子量： 185 kDa

别名： CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1, HER-2, erb-b2 receptor tyrosine kinase 2

应用 | 种属

WB H,M

规格：

100 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	酪氨酸蛋白激酶受体erbB-2
别名	CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1, HER-2, erb-b2 receptor tyrosine kinase 2
Uniprot ID	P70424
免疫原	小鼠Receptor tyrosine-protein kinase erbB-2重组蛋白
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	139 kDa / 185 kDa

应用

WB 免疫印迹

物种:人, 小鼠

稀释比:1: 500-1: 1000

阳性样品:

背景

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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