| 蛋白质全称 | Toll样受体9 |
|---|---|
| 别名 | TLR9, CD289, toll like receptor 9, Toll like receptor 9 isoform A precursor, Toll like receptor 9 isoform B |
| Uniprot ID | Q9EQU3, Q9NR96 |
| 免疫原 | KLH偶联的小鼠TLR9合成肽 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 亚细胞定位 | 胞质囊泡, 内质网, 内体, 溶酶体, 膜 |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Controls lymphocyte response to Helicobacter infection (By similarity).
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