400-6027-270
产品信息
| 蛋白质全称 | 铁死亡抑制蛋白1 |
|---|---|
| 别名 | AIFM2, AMID, PRG3, p53-responsive gene 3 protein, FSP1 |
| Uniprot ID | Q9BRQ8 |
| 免疫原 | KLH偶联的人FSP1合成肽 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 预测分子量./观测分子量. | 41 kDa / 41 kDa |
应用
WB 免疫印迹
物种:小鼠, 大鼠
稀释比:1: 500-1: 1000
阳性样品:
背景
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
储存条件
储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.
储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.
图像
需要技术支持？
如果您有任何问题或如果您在实验过程中遇到问题，或需要更详细的技术指导，请联系我们的技术支持团队
400-6027-270
联系我们
如果您对我们的公司或产品有任何疑问，欢迎随时联系我们
湖北省武汉市东湖新技术开发区高新二路388号生物医药加速器22栋5楼 
400-6027-270 
鄂公网安备42018502008544号