| 蛋白质全称 | 氧甾醇受体LXR-α |
|---|---|
| 别名 | NR1H3,LXR-a,LXRA,RLD-1,Liver X receptor alpha,nuclear receptor subfamily 1 group H member 3 |
| Uniprot ID | Q9Z0Y9 |
| 免疫原 | KLH偶联的小鼠LXRα合成肽 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 亚细胞定位 | 细胞核 |
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
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