| 蛋白质全称 | 端粒重复序列结合因子2相互作用蛋白1 |
|---|---|
| 别名 | TERF2IP,DRIP5,RAP1,TERF2 interacting protein |
| Uniprot ID | Q91VL8 |
| 免疫原 | 小鼠RAP1重组蛋白 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 亚细胞定位 | 细胞核, 细胞质 |
| 预测分子量./观测分子量. | 45 kDa / 46 kDa |
Telomeric repeat-binding factor 2-interacting protein 1 acts both as a regulator of telomere function and as a transcription regulator. it is involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length.
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