Anti-p75 NGF Receptor 兔多克隆抗体-生长因子及受体-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

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Anti-p75 NGF Receptor 兔多克隆抗体

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￥1900

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货号： K1346386-100

预测分子量： 46 kDa

观测分子量： 65 kDa

别名： CD271,Gp80 LNGFR,NGF receptor,NGFR,p75,p75 ICD,p75(NTR),p75NTR,TNFRSF16

应用 | 种属

WB H,M,R

规格：

100 μL

产品描述
应用
背景
储存条件
图像

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产品信息

蛋白质全称	肿瘤坏死因子受体超家族成员16
别名	CD271,Gp80 LNGFR,NGF receptor,NGFR,p75,p75 ICD,p75(NTR),p75NTR,TNFRSF16
Uniprot ID	Q9Z0W1
免疫原	KLH偶联的小鼠P75NTR合成磷酸肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	46 kDa / 65 kDa

应用

WB 免疫印迹

物种:人,小鼠,大鼠

稀释比:1:300-1:400

阳性样品:PC-12细胞

背景

Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.; (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs.; [Isoform 2]: Does not bind NGF, BDNF, NTF3, and NTF4.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像

WB检测p75 NGF Receptor蛋白(货号 K1346386).
样品: 经RIPA裂解液(货号KSG2002)处理的蛋白质.
封闭: 3%脱脂牛奶(货号KSGC310001)溶于TBST溶液, 室温孵育1小时.
—抗: 1: 300稀释, 4℃ 孵育过夜.
二抗: HRP标记山羊抗兔IgG (H+L) (货号KB69909), 1: 5000稀释, 室温孵育1小时.