背景
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins.Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18,SEPT5,SYN1,DNM1,AMPH,SYNJ1,CDK16, RAC1,RHOA,CDC42,TONEBP/NFAT5,MAPT/TAU,MAP1B, histone H1,p53/TP53,HDAC1,APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival,migration and differentiation, axonal and neurite growth,synaptogenesis,oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins.
储存条件
储存条件:储存条件在:-20℃下储存一年, 避免反复冻融.
储存缓冲液:含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.