Anti-Natriuretic peptides A 兔多克隆抗体-激素及受体-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

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Anti-Natriuretic peptides A 兔多克隆抗体

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货号： K1346755-100

亚细胞定位：分泌型

别名： ANF,ANP,ATFB6,Atrial natriuretic factor,Atrial natriuretic peptide,CDD ANF,CDP,NPPA,PND,Prepronatriodilatin

应用 | 种属

IHC/IF M,R

规格：

100 μL

产品描述
应用
背景
储存条件
图像

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产品信息

蛋白质全称	心房利钠肽
别名	ANF,ANP,ATFB6,Atrial natriuretic factor,Atrial natriuretic peptide,CDD ANF,CDP,NPPA,PND,Prepronatriodilatin
Uniprot ID	P05125
免疫原	KLH偶联的小鼠ANP合成肽
抗体亚型	IgG
纯化方式	亲和纯化
亚细胞定位	分泌型

应用

IHC/IF 免疫组织化学/免疫荧光

物种:小鼠,大鼠

稀释比:1:150-1:300

阳性样品:白色脂肪

背景

Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses. Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance. Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts. Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension. In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像

IHC检测Natriuretic peptides A蛋白(货号 K1346755).
样品: 小鼠白色脂肪, 4%多聚甲醛 (货号KSG1101) 固定12-24小时.
抗原修复: Tris-EDTA抗原修复液(pH 9.0) (KSG1203), 98℃, 20分钟.
—抗: 1: 200稀释, 4℃ 孵育过夜.
二抗: S-vision免疫组化多聚二抗(山羊抗兔),即用型 (货号KB3906), 室温孵育20分钟.

IHC检测Natriuretic peptides A蛋白(货号 K1346755).
样品: 大鼠白色脂肪, 4%多聚甲醛 (货号KSG1101) 固定12-24小时.
抗原修复: Tris-EDTA抗原修复液(pH 9.0) (KSG1203), 98℃, 20分钟.
—抗: 1: 200稀释, 4℃ 孵育过夜.
二抗: S-vision免疫组化多聚二抗(山羊抗兔),即用型 (货号KB3906), 室温孵育20分钟.