| 蛋白质全称 | 丝切蛋白1 |
|---|---|
| 别名 | CFL1,CFL,HEL-S-15,Cofilin,Cofilin 1,18 kDa phosphoprotein, p18,Cofilin,non-muscle isoform,Cfl1,HEL-S-15,epididymis secretory protein Li 15 |
| Uniprot ID | P18760 |
| 免疫原 | 小鼠Cofilin重组蛋白/KLH偶联的小鼠Cofilin合成肽 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 亚细胞定位 | 细胞膜, 细胞突起, 细胞质, 细胞骨架, 细胞核 |
| 预测分子量./观测分子量. | 19 kDa / 19 kDa |
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a member of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.
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