| 蛋白质全称 | SMAD同源蛋白2 |
|---|---|
| 别名 | SMAD2, JV18, MADH2, MADR2, hMAD-2, hSMAD family member 2, Mothers against DPP homolog 2, hSMAD2, JV18-1 |
| Uniprot ID | Q62432 |
| 免疫原 | KLH偶联的小鼠Smad2合成肽 |
| 抗体亚型 | IgG |
| 纯化方式 | 亲和纯化 |
| 预测分子量./观测分子量. | 52 kDa / 58 kDa |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
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