Anti-ABR 兔多克隆抗体-小G蛋白相关-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-ABR 兔多克隆抗体

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货号： K1344532-100

预测分子量： 98 kDa

观测分子量： 120 kDa

别名： Active BCR related,Active BCR related gene,MDB,abr,Active breakpoint cluster region related protein

应用 | 种属

WB M,R

规格：

100 μL

产品描述
应用
背景
储存条件
图像

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产品信息

蛋白质全称	活性断点簇区域相关蛋白
别名	Active BCR related,Active BCR related gene,MDB,abr,Active breakpoint cluster region related protein
Uniprot ID	Q5SSL4
免疫原	KLH偶联的小鼠ABR合成肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	98 kDa / 120 kDa

应用

WB 免疫印迹

物种:小鼠,大鼠

稀释比:1:300-1:600

阳性样品:肺

背景

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像

WB检测ABR蛋白(货号 K1344532).
样品: 经RIPA裂解液(货号KSG2002)处理的蛋白质.
封闭: 3%脱脂牛奶(货号KSGC310001)溶于TBST溶液, 室温孵育1小时.
—抗: 1: 300稀释, 4℃ 孵育过夜.
二抗: HRP标记山羊抗兔IgG (H+L) (货号KB69909), 1: 5000稀释, 室温孵育1小时.