Anti-MRP1 兔多克隆抗体-能量代谢,通道蛋白-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

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Anti-MRP1 兔多克隆抗体

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￥1900

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货号： K135823-100

亚细胞定位：细胞膜

别名： ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,ABCC1,ABCC,LTC4 transporter,ABC29,ABCC 1,GSX,Multidrug resistance associated protein 1,Multidrug resistance protein,MRP,Multiple drug resistance protein 1,Abcc1,Mrp1

应用 | 种属

IHC/IF H,M

规格：

100 μL

产品描述
应用
背景
储存条件
图像

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产品信息

蛋白质全称	多药耐药相关蛋白1
别名	ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,ABCC1,ABCC,LTC4 transporter,ABC29,ABCC 1,GSX,Multidrug resistance associated protein 1,Multidrug resistance protein,MRP,Multiple drug resistance protein 1,Abcc1,Mrp1
Uniprot ID	P33527
免疫原	KLH偶联的人MRP1合成肽
抗体亚型	IgG
纯化方式	亲和纯化
亚细胞定位	细胞膜

应用

IHC/IF 免疫组织化学/免疫荧光

物种:人,小鼠

稀释比:1:500-1:2000

阳性样品:肺癌, 胃

背景

MRP1 is a member of the MRP subfamily of ATPbindingcassette (ABC) transporters . MRP1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agent sand the glutathione (GSH) conjugates of these compounds. MRP1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids,leukotrienes and prostaglandins. Although MRP1 is generally expressed in normaltissue, upregulation of MRP1 has been found in avariety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer . Research studies show that over expression of MRP1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像

IF检测MRP1蛋白(货号 K135823)(红色）.
样品: 人肺癌, 4%多聚甲醛 (货号KSG1101) 固定12-24小时.
抗原修复: Tris-EDTA抗原修复液(pH 9.0) (KSG1203), 98℃, 20分钟.
封闭: 3% BSA（货号KSGC305010）的PBS溶液, 室温孵育30分钟.
—抗: 1: 1300稀释, 4℃ 孵育过夜.
二抗: Cy3标记山羊抗兔IgG (H+L) (货号KB63909), 1: 300稀释, 室温孵育1小时.

IF检测MRP1蛋白(货号 K135823)(红色）.
样品: 人胃, 4%多聚甲醛 (货号KSG1101) 固定12-24小时.
抗原修复: Tris-EDTA抗原修复液(pH 9.0) (KSG1203), 98℃, 20分钟.
封闭: 3% BSA（货号KSGC305010）的PBS溶液, 室温孵育30分钟.
—抗: 1: 1300稀释, 4℃ 孵育过夜.
二抗: Cy3标记山羊抗兔IgG (H+L) (货号KB63909), 1: 300稀释, 室温孵育1小时.