Anti-Insig1 兔多克隆抗体-能量代谢-科普欣生物 Cookbio 抗体|仪器|耗材-武汉科普欣生物科技有限公司

热门搜索： CD3 Actin GFP

Anti-Insig1 兔多克隆抗体

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￥1900

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货号： K1344253-100

预测分子量： 28 kDa

观测分子量： 35 kDa

别名： CL 6, INSIG-1, INSIG1, insulin induced gene 1, Insulin induced gene 1 protein

应用 | 种属

WB M,R

规格：

100 μL

产品描述
应用
背景
储存条件
图像

产品信息

蛋白质全称	胰岛素诱导基因1蛋白
别名	CL 6, INSIG-1, INSIG1, insulin induced gene 1, Insulin induced gene 1 protein
Uniprot ID	Q8BGI3
免疫原	KLH偶联的小鼠Insig1合成肽
抗体亚型	IgG
纯化方式	亲和纯化
预测分子量./观测分子量.	28 kDa / 35 kDa

应用

WB 免疫印迹

物种:小鼠, 大鼠

稀释比:1: 800-1: 1500

阳性样品:

背景

Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR . Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum . In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi.

储存条件

储存条件：储存条件在：-20℃下储存一年, 避免反复冻融.

储存缓冲液：含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

图像